Lithium Hydroxide → HCID 45110614, compound

Participants

Reaction Steps

To a solution of 4-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-benzoic acid ethyl ester (10 mg, 21 μmol in THF/MeOH 2/1 (150 μl) was a added a 1 N aqueous lithium hydroxide solution (120 μl, 120 μmmol) at ambient temperature under an argon atmosphere. The reaction mixture was stirred for 12 h at ambient temperature, poured onto ice water/1 N aqueous HCl solution 1/1 and extracted two times with iPrOAc. The combined extracts were washed with ice water/brine 1/1 and dried over Na2SO4. After filtration the solvent was removed under reduced pressure to give the title compound (10 mg, 22 umol; quant.) as yellow solid. MS: m/e=455.4 [M+H+].

Provenance & Evidence