2-Fluorophenyl isocyanate → HCID 45110615, compound

HRID 1690511Notes

Reaction equation

HRID 1690511 reaction equation
[CH:1]1([NH:7][C:8]2[N:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:10]=[C:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[N:30]=[C:31]=[O:32]>C1(C)C=CC=CC=1>[CH:1]1([N:7]([C:8]2[N:9]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:10]=[C:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)[C:31]([NH:30][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[F:23])=[O:32])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 855882-Fluorophenyl isocyanateHCID 12318206N-Cyclohexyl-2-phenyl-2H-indazol-3-amine

Product 1

HCID 45110615HCID 45110615, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, cyclohexyl-(2-phenyl-2H-indazol-3-yl)-amine (example 1.1) was reacted with 1-fluoro-2-isocyanato-benzene ([16744-98-2]) in toluene for 48 h under reflux conditions to give the title compound as colorless oil. MS: m/e=429.5 [M+H+].

Sources & evidence

ORD record
ord-4b01e33f14da41be9106bb9bbf5a6ac8
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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