反应详情

Sodium borohydride (245 mg, 6.46 mmol) was added to a suspension of (2-phenyl-2H-indazol-3-yl)-[1-phenyl-methylidene]-amine (480 mg, 1.61 mmol) in ethanol (13 ml) at ambient temperature under an argon atmosphere. The reaction mixture was stirred at ambient temperature for 12 h, poured onto ice water/aqueous NaHCO3 solution 1/1 and extracted two times with iPrOAc. The combined extracts were washed with ice water/brine 1/1 and dried over Na2SO4. After filtration the solvent was removed under reduced pressure, the resulting yellow oil was purified by column chromatography (silica gel, iPrOAc/heptane) to give the title compound (314 mg, 1.05 mmol; 65%) as yellow oil. MS: m/e=300.4 [M+H+].

1. additionpoured onto ice water/aqueous NaHCO3 solution 1/1
2. extractionextracted two times with iPrOAc
3. washThe combined extracts were washed with ice water/brine 1/1
4. dry with materialdried over Na2SO4
5. filtrationAfter filtration the solvent
6. customwas removed under reduced pressure
7. customthe resulting yellow oil was purified by column chromatography (silica gel, iPrOAc/heptane)