HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine → 4-{3-Benzyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine | HCID 66905008 | — |
| Reactant | 3-Chloro-4-isocyanato-benzoic acid methyl ester | HCID 86640262 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-{3-Benzyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid methyl ester | HCID 66905259 | — |
Reaction Steps
In analogy to the procedure described in example 1.2, benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine (example 7.1) was reacted with 3-chloro-4-isocyanato-benzoic acid methyl ester in toluene for 72 h under reflux conditions to give the title compound as yellow oil. MS: m/e=547.0 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-c6d9ee99bc8b431aa9989488590d3ebb |
| Source note | uspto-grants-2012_04 |