Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1690521Generated: October 30, 2026

Benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine → 4-{3-Benzyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid methyl ester

https://huagongshe.com/reaction/1690521

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amineHCID 66905008—
Reactant3-Chloro-4-isocyanato-benzoic acid methyl esterHCID 86640262—
SolventTolueneHCID 1140—
Product4-{3-Benzyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid methyl esterHCID 66905259—

Reaction Steps

In analogy to the procedure described in example 1.2, benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine (example 7.1) was reacted with 3-chloro-4-isocyanato-benzoic acid methyl ester in toluene for 72 h under reflux conditions to give the title compound as yellow oil. MS: m/e=547.0 [M+H+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153663B2
Source datasetuspto-grants-2012_04
ORD IDord-c6d9ee99bc8b431aa9989488590d3ebb
Source noteuspto-grants-2012_04