HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminotetrahydropyran → [2-(4-Chloro-phenyl)-2H-indazol-3-yl]-(tetrahydro-pyran-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | 1-Butyl-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea | HCID 45110616 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | [2-(4-Chloro-phenyl)-2H-indazol-3-yl]-(tetrahydro-pyran-4-yl)-amine | HCID 66905236 | — |
Reaction Steps
In analogy to the procedure described in example 4.1, 3-chloro-2-(4-chloro-phenyl)-2H-indazole (Ardakani, Manouchehr; Smalley, Robert K.; Smith, Richard H., Synthesis (1979), (4), 308-9) was reacted with tetrahydro-pyran-4-ylamine ([38041-19-9]) in N-methyl 2-pyrrolidone for 48 h at 175° C. in a sealed tube to give the title compound as yellow solid. MS: m/e=328.4 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-8ae5af3260a4497cb312234c54415dd4 |
| Source note | uspto-grants-2012_04 |