HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexyl isocyanate → 1-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(tetrahydro-pyran-4-yl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexyl isocyanate | HCID 18502 | — |
| Reactant | [2-(4-Chloro-phenyl)-2H-indazol-3-yl]-(tetrahydro-pyran-4-yl)-amine | HCID 66905236 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(tetrahydro-pyran-4-yl)-urea | HCID 45110746 | — |
Reaction Steps
In analogy to the procedure described in example 1.2, [2-(4-chloro-phenyl)-2H-indazol-3-yl]-(tetrahydro-pyran-4-yl)-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in toluene for 5 days under reflux conditions to give the title compound as yellow oil. MS: m/e=453.3 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-e57123640e5a42fdb6911dbffa77aa60 |
| Source note | uspto-grants-2012_04 |