HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → [2-(4-Chloro-phenyl)-2H-indazol-3-yl]cyclohexyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 1-Butyl-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea | HCID 45110616 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | [2-(4-Chloro-phenyl)-2H-indazol-3-yl]cyclohexyl-amine | HCID 66905444 | — |
Reaction Steps
In analogy to the procedure described in example 4.1, 3-chloro-2-(4-chloro-phenyl)-2H-indazole (Ardakani, Manouchehr; Smalley, Robert K.; Smith, Richard H., Synthesis (1979), (4), 308-9) was reacted with cyclohexylamine ([108-91-8]) in N-methyl 2-pyrrolidone for 48 h at 175° C. in a sealed tube to give the title compound as brown oil. MS: m/e=327.3 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-354194d9cab245b998995838c8d2e1e2 |
| Source note | uspto-grants-2012_04 |