Cyclohexyl isocyanate → 1-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-1,3-dicyclohexyl-urea

HRID 1690526Notes

Reaction equation

HRID 1690526 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([NH:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[C:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[CH:24]1([N:30]=[C:31]=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([N:17]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:31]([NH:30][CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)=[O:32])=[C:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 66905444[2-(4-Chloro-phenyl)-2H-indazol-3-yl]cyclohexyl-amine

Product 1

HCID 461827621-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-1,3-dicyclohexyl-urea

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, [2-(4-chloro-phenyl)-2H-indazol-3-yl]-cyclohexyl-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in toluene for 24 h under reflux conditions to give the title compound as yellow oil. MS: m/e=451.1 [M+H+].

Sources & evidence

ORD record
ord-cfcde0f85eae45e2841bd8c222019af1
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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