butyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine → 4-{3-Butyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid methyl ester

HRID 1690527Notes

Reaction equation

HRID 1690527 reaction equation
[CH2:1]([NH:5][C:6]1[N:7]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[N:8]=[C:9]2[C:14]=1[CH:13]=[CH:12][CH:11]=[CH:10]2)[CH2:2][CH2:3][CH3:4].[CH3:22][O:23][C:24](=[O:35])[C:25]1[CH:30]=[CH:29][C:28]([N:31]=[C:32]=[O:33])=[C:27]([Cl:34])[CH:26]=1>C1(C)C=CC=CC=1>[CH3:22][O:23][C:24](=[O:35])[C:25]1[CH:30]=[CH:29][C:28]([NH:31][C:32]([N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:6]2[N:7]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)[N:8]=[C:9]3[C:14]=2[CH:13]=[CH:12][CH:11]=[CH:10]3)=[O:33])=[C:27]([Cl:34])[CH:26]=1

Participants

4

Reactant 2

HCID 66905446butyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amineHCID 866402623-Chloro-4-isocyanato-benzoic acid methyl ester

Product 1

HCID 669055284-{3-Butyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid methyl ester

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, butyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine (example 4.1) was reacted with 3-chloro-4-isocyanato-benzoic acid methyl ester (example 9.1) in toluene for 5 d under reflux conditions to give the title compound as colorless foam. MS: m/e=510.9 [M+H+].

Sources & evidence

ORD record
ord-05076269729f41c29b072d948434abea
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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