HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl 4-isocyanato-3-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | Methyl 4-amino-3-methylbenzoate | HCID 2736799 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4-isocyanato-3-methylbenzoate | HCID 86069399 | — |
Reaction Steps
In analogy to the procedure described in example 9.1, 4-amino-3-methyl-benzoic acid methyl ester ([18595-14-7]) was reacted with triphosgene in the presence of Et3N in CH2Cl2 under reflux conditions for 14 h to give the title compound as brown solid. MS: m/e=191.1 [M+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-ba3aa4902c194b83b9af8673fe56a8f8 |
| Source note | uspto-grants-2012_04 |