HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → [2-(4-Chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Cyclohexanone | HCID 7967 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 2-(4-Chloro-phenyl)-5,6-difluoro-2H-indazol-3-ylamine | HCID 66905169 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [2-(4-Chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-amine | HCID 66905283 | — |
Reaction Steps
In analogy to the procedure described in example 1.1, a mixture of 2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-ylamine and cyclohexanone ([108-94-1]) was reacted with sodium triacetoxyborohydride in the presence of acetic acid in CH2Cl2 under reflux conditions for 96 h to give the title compound as light brown solid. MS: m/e=362.5 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-21bc9d34f77f4cc087271ff3f9a10570 |
| Source note | uspto-grants-2012_04 |