HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-Chloro-4-{3-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-3-cyclohexyl-ureido}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 3-Chloro-4-{3-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-3-cyclohexyl-ureido}-benzoic acid methyl ester | HCID 66905872 | — |
| Solvent | Dichloromethane heptane | HCID 21907733 | — |
| Product | 3-Chloro-4-{3-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-3-cyclohexyl-ureido}-benzoic acid | HCID 45110886 | — |
Reaction Steps
In analogy to the procedure described in example 2.2, 3-chloro-4-{3-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-3-cyclohexyl-ureido}-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 24 h at 60° C. to give the title compound as off-white solid. MS: m/e=559.3 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-85232b6568da4e54bd68271e74384ba9 |
| Source note | uspto-grants-2012_04 |