HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (3-Chloro-4-isocyanato-phenyl)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | (4-Amino-3-chloro-phenyl)-acetic acid ethyl ester | HCID 17859298 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3-Chloro-4-isocyanato-phenyl)-acetic acid ethyl ester | HCID 86640265 | — |
Reaction Steps
In analogy to the procedure described in example 9.1, (4-amino-3-chloro-phenyl)-acetic acid ethyl ester was reacted with triphosgene in the presence of Et3N in CH2Cl2 under reflux conditions for 48 h to give the title compound as brown solid which was used in the next step without further purification. MS: m/e=257.0 [M+NH4+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-e92f7241f5e94c5981f90685ba9be339 |
| Source note | uspto-grants-2012_04 |