HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (3-Fluoro-4-isocyanato-phenoxy)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | Methyl 2-[(4-amino-3-fluorophenyl)oxy]acetate hydrochloride | HCID 66905560 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3-Fluoro-4-isocyanato-phenoxy)-acetic acid methyl ester | HCID 86640266 | — |
Reaction Steps
In analogy to the procedure described in example 9.1, (4-amino-3-fluoro-phenoxy)-acetic acid methyl ester hydrochloride (Kori, Masakuni; Mild, Takashi; Nishimoto, Tomoyuki; Tozawa, Ryuichi. PCT Int. Appl. (2001), WO 2001098282 A1) was reacted with triphosgene in the presence of Et3N (3.5 eq.) in CH2Cl2 under reflux conditions for 14 h to give the title compound as brown solid. MS: m/e=243.1 [M+NH4+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-cb9fa308671943599fc3826a20d81f8f |
| Source note | uspto-grants-2012_04 |