(E)-3-(3-Fluoro-4-nitro-phenyl)-acrylic acid tert-butyl ester → Tert-butyl 3-(4-amino-3-fluorophenyl)propanoate

Participants

Reaction Steps

A solution of (E)-3-(3-fluoro-4-nitro-phenyl)-acrylic acid tert-butyl ester (804 mg, 3.01 mmol) in ethyl acetate (10 ml) was hydrogenated on 10% palladium on charcoal for 30 min at 1.5 bar. The suspension was filtered, the filter cake washed with ethyl acetate and the filtrate evaporated and dried under high vacuum to give the product as light brown solid (713 mg, 3 mmol; 99%). This material was pure enough for the next step. MS: m/e=240.0 [M+H+].

Provenance & Evidence