Triethylamine → 1-[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(3-ethoxy-phenyl)-urea

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Cyclohexyl isocyanate	HCID 18502	—
Reactant	[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine	HCID 66905404	—
Solvent	1,2-Dichloroethane	HCID 11	—
Product	1-[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(3-ethoxy-phenyl)-urea	HCID 45111328	—

Reaction Steps

In analogy to the procedure described in example 1.2, [5-chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in 1,2-dichloroethane in the presence of Et3N (3 eq.) for 4 days under reflux conditions to give the title compound as colorless foam. MS: m/e=523.3 [M+H+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08153663B2
Source dataset	uspto-grants-2012_04
ORD ID	ord-527921a53d2e412c9dffc5861238d93c
Source note	uspto-grants-2012_04