Cyclobutylamine → [2-(4-Chloro-phenyl)-2H-indazol-3-yl]-cyclobutyl-amine

Participants

Role	Name	HCID	Charge
Reactant	Cyclobutylamine	HCID 75645	—
Reactant	1-Butyl-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea	HCID 45110616	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-cyclobutyl-amine	HCID 66905392	—

Reaction Steps

In analogy to the procedure described in example 4.1, 3-chloro-2-(4-chloro-phenyl)-2H-indazole (Ardakani, Manouchehr; Smalley, Robert K.; Smith, Richard H., Synthesis (1979), (4), 308-9) was reacted with cyclobutylamine ([2516-34-9]) in N-methyl 2-pyrrolidone for 3 days at 175° C. in a sealed tube to give the title compound as yellow solid. MS: m/e=298.4 [M+H+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08153663B2
Source dataset	uspto-grants-2012_04
ORD ID	ord-ed278a874a2246138e3d2e9d6d7c29fc
Source note	uspto-grants-2012_04