HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Isocyanato-4-methyl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | Methyl 3-amino-4-methylbenzoate | HCID 337778 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Isocyanato-4-methyl-benzoic acid methyl ester | HCID 83383254 | — |
Reaction Steps
In analogy to the procedure described in example 9.1, 3-amino-4-methyl-benzoic acid methyl ester ([18595-18-1]) was reacted with triphosgene in the presence of Et3N in CH2Cl2 under reflux conditions for 16 h to give the title compound as brown solid which was used in the next step without further purification. MS: m/e=191 [M+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-ce474ea390954175a0d0ad3e96ce34f7 |
| Source note | uspto-grants-2012_04 |