Cyclohexyl isocyanate → HCID 45111625, compound

HRID 1690592Notes

Reaction equation

HRID 1690592 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([NH:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[C:15]3[C:10]([CH:11]=[C:12]([F:24])[CH:13]=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[CH:25]1([N:31]=[C:32]=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]([N:17]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:32]([NH:31][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:33])=[C:15]3[C:10]([CH:11]=[C:12]([F:24])[CH:13]=[CH:14]3)=[N:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 66905291HCID 66905291, compound

Product 1

HCID 45111625HCID 45111625, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, [2-(4-chloro-phenyl)-6-fluoro-2H-indazol-3-yl]-cyclohexyl-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in toluene for 5 days under reflux conditions to give the title compound as off-white solid. MS: m/e=469.4 [M+H+].

Sources & evidence

ORD record
ord-0643100c820041f18cb641a2a5a1e91f
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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