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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1690642Generated: October 31, 2026

4-Piperidinol, 1-methyl- → 4-Hydroxy-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromide

https://huagongshe.com/reaction/1690642

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Piperidinol, 1-methyl-HCID 66048—
Reactant2-bromo-N-(isoxazol-3-yl)acetamideHCID 13362919—
Reactant2-bromo-N-(pyrazin-2-yl)acetamideHCID 44542669—
Reactant(1R/S,3R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromideHCID 87357711—
Product4-Hydroxy-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromideHCID 86634221—

Reaction Steps

This compound is prepared by an analogous method to (1R/S,3R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromide (Intermediate C) by replacing (R)-1-methyl-piperidin-3-ol (step C3) with 1-methyl-piperidin-4-ol and by replacing 2-bromo-N-isoxazol-3-yl-acetamide (Intermediate A) with 2-bromo-N-pyrazin-2-yl-acetamide (Intermediate G).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153669B2
Source datasetuspto-grants-2012_04
ORD IDord-5bea74143eba4caaa7e632ccb78cfaa3
Source noteuspto-grants-2012_04