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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1690645Generated: October 31, 2026

(3-Bromopropyl)benzene → 4-Hydroxy-1-methyl-1-(3-phenyl-propyl)-piperidinium bromide

https://huagongshe.com/reaction/1690645

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-Bromopropyl)benzeneHCID 12503—
Reactant4-Piperidinol, 1-methyl-HCID 66048—
Reactant2-bromo-N-(isoxazol-3-yl)acetamideHCID 13362919—
Reactant(1R/S,3R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromideHCID 87357711—
Product4-Hydroxy-1-methyl-1-(3-phenyl-propyl)-piperidinium bromideHCID 66902549—

Reaction Steps

This compound is prepared by an analogous method to (1R/S,3R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromide (Intermediate C) by replacing (R)-1-methyl-piperidin-3-ol (step C3) with 1-methyl-piperidin-4-ol and by replacing 2-bromo-N-isoxazol-3-yl-acetamide (Intermediate A) with 3-phenyl propylbromide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153669B2
Source datasetuspto-grants-2012_04
ORD IDord-996c7f10cb9f47d68e007a9861792b5e
Source noteuspto-grants-2012_04