HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinol, 1-methyl- → 4-Hydroxy-1-methyl-1-(2-phenoxy-ethyl)-piperidinium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinol, 1-methyl- | HCID 66048 | — |
| Reactant | Benzene, (2-bromoethoxy)- | HCID 68526 | — |
| Reactant | 2-bromo-N-(isoxazol-3-yl)acetamide | HCID 13362919 | — |
| Reactant | (1R/S,3R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromide | HCID 87357711 | — |
| Product | 4-Hydroxy-1-methyl-1-(2-phenoxy-ethyl)-piperidinium bromide | HCID 66902243 | — |
Reaction Steps
This compound is prepared by an analogous method to (1R/S,3R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromide (Intermediate C) by replacing (R)-1-methyl-piperidin-3-ol (step C3) with 1-methyl-piperidin-4-ol and by replacing 2-bromo-N-isoxazol-3-yl-acetamide (Intermediate A) with 2-phenoxy-ethylbromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153669B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6e7a44eb210640bbac90ff17a9fad4e9 |
| Source note | uspto-grants-2012_04 |