HRID1690650

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[N+]1(CC(=O)Nc2cnccn2)CCC(O)CC1.[Br-]

HCID86634221

未命名化合物

2 次

结构：C[N+]1(CC(=O)Nc2ccon2)CCC[C@@H]1CO.[Br-]

HCID131729615

未命名化合物

结构：C[N+]1(C(C(N)=O)c2ccon2)CCCC1COC(=O)C(O)(c1ccccc1)C1CCCCC1.[Br-]

HCID131729617

未命名化合物

PRODUCTS

生成物

结构：C[N+]1(CC(=O)Nc2cnccn2)CCC(OC(=O)C(O)(c2ccccc2)C2CCCCC2)CC1.[Br-]

HCID87197894

未命名化合物

PROCEDURE

实验过程

This compound is prepared by an analogous method to (1R/S,2R)-2-((R/S)-(2-Cyclohexyl-2-hydroxy-2-phenyl-acetoxymethyl)-1-(isoxazol-3-yl carbamoylmethyl)-1-methyl-pyrrolidinium bromide (Example 1) by replacing (1R/S,2R)-2-hydroxymethyl-1-(isoxazol-3-ylcarbamoyl-methyl)-1-methyl-pyrrolidinium bromide (Intermediate B) with 4-hydroxy-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromide (Intermediate H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ffff1a0573f547d0b8f58b8a77c06dd4
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08153669B2
来源说明: uspto-grants-2012_04

反应 SMILES

[Br-:1].[CH:2]1([C:8]([OH:34])([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:9]([O:11][CH2:12]C2CCC[N+]2(C(C2C=CON=2)C(=O)N)C)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[Br-].OC[C@H]1CCC[N+]1(CC(=O)NC1C=CON=1)C.[Br-].OC1[CH2:60][CH2:59][N+:58]([CH3:71])([CH2:61][C:62](=[O:70])[NH:63][C:64]2[CH:69]=[N:68][CH:67]=[CH:66][N:65]=2)[CH2:57][CH2:56]1>>[Br-:1].[CH:2]1([C:8]([OH:34])([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:9]([O:11][CH:12]2[CH2:56][CH2:57][N+:58]([CH3:71])([CH2:61][C:62](=[O:70])[NH:63][C:64]3[CH:69]=[N:68][CH:67]=[CH:66][N:65]=3)[CH2:59][CH2:60]2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1