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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1690652Generated: October 30, 2026

alpha-Cyclopentylmandelic acid → 2-Cyclopentyl-2-hydroxy-2-phenyl-acetoxy-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromide

https://huagongshe.com/reaction/1690652

Reaction equation

Participants

RoleNameHCIDCharge
Reactantalpha-Cyclopentylmandelic acidHCID 98283—
Reactant4-(2-Cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromideHCID 87197894—
Product2-Cyclopentyl-2-hydroxy-2-phenyl-acetoxy-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromideHCID 131729621—

Reaction Steps

This compound is prepared by an analogous method to 4-(2-cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromide (Example 4) by replacing cyclohexyl-hydroxy-phenyl-acetic acid with cyclopentyl-mandelic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153669B2
Source datasetuspto-grants-2012_04
ORD IDord-27e21a739ab942e88efd404ef2ca8884
Source noteuspto-grants-2012_04