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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1690655Generated: October 31, 2026

Benzilic acid → (1R/S,3R)-3-(2-Hydroxy-2,2-diphenyl-acetoxymethyl)-1-(isoxazol-3-ylcarbamoyl methyl)-1-methyl-piperidinium bromide

https://huagongshe.com/reaction/1690655

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzilic acidHCID 6463—
Reactant(R/S)-(2-Cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-methyl-piperidinium bromideHCID 131729619—
Product(1R/S,3R)-3-(2-Hydroxy-2,2-diphenyl-acetoxymethyl)-1-(isoxazol-3-ylcarbamoyl methyl)-1-methyl-piperidinium bromideHCID 131729623—

Reaction Steps

This compound is prepared by an analogous method (1R/S,2R)-3-((R/S)-(2-cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromide: (Example 2) by replacing cyclohexyl-hydroxy-phenyl-acetic acid with benzilic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153669B2
Source datasetuspto-grants-2012_04
ORD IDord-23cfc3dfbb454a188a1b5359f2f2de37
Source noteuspto-grants-2012_04