Water → 4-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromide

Participants

Reaction Steps

To a stirred solution comprising hydroxy-diphenyl-acetic acid 1-methyl-piperidin-4-yl ester (Intermediate F) (0.25 g, 0.77 mmol) in acetonitrile (5 ml) under an inert atmosphere of argon is added 2-bromo-N-isoxazol-3-yl-acetamide (Intermediate A). The reaction mixture is stirred overnight at room temperature and then water is added. Acetonitrile is removed in vacuo and the resulting mixture is decanted into a clean flask and left overnight. The solid that formed is filtered to yield the titled product.

Provenance & Evidence