HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-bromo-N-(isoxazol-3-yl)acetamide → 4-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-bromo-N-(isoxazol-3-yl)acetamide | HCID 13362919 | — |
| Reactant | 2-bromo-N-(pyrazin-2-yl)acetamide | HCID 44542669 | — |
| Reactant | 4-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromide | HCID 86634223 | — |
| Product | 4-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-piperidinium bromide | HCID 86634225 | — |
Reaction Steps
This compound is prepared by an analogous method to 4-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-piperidinium bromide (Example 13) by replacing 2-bromo-N-isoxazol-3-yl-acetamide (Intermediate A) with 2-bromo-N-pyrazin-2-yl-acetamide (Intermediate G).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153669B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-759a1b8d757245798d17cc014c2ef7f6 |
| Source note | uspto-grants-2012_04 |