5-Oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile → HCID 86628782, compound

HRID 1690685Notes

Reaction equation

HRID 1690685 reaction equation
[C:1]([C:3]1[CH:4]=C2C(=[CH:11][CH:12]=1)C(=O)CCC2)#[N:2].Cl.[CH2:15]([C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([NH:31]N)[CH:26]=2)=[CH:21][CH:20]=1)[CH2:16][CH2:17][CH3:18]>>[CH2:15]([C:19]1[CH:24]=[CH:23][C:22]([C:25]2[C:26]3[C:27]4[NH:31][C:19]5[C:24]([C:28]=4[CH2:29][CH2:30][C:11]=3[CH:12]=[C:3]([C:1]#[N:2])[CH:4]=2)=[CH:23][CH:22]=[CH:21][CH:20]=5)=[CH:21][CH:20]=1)[CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 108991325-Oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrileHCID 66904838(4'-Butyl-biphenyl-3-yl)-hydrazine hydrochloride

Product 1

HCID 86628782HCID 86628782, compound

Procedure

This material is prepared from commercially available 6-cyanotetralone and (4′-Butyl-biphenyl-3-yl)-hydrazine hydrochloride (example 70, step 1) in the same manner and similar yield as example 1, step 3. LC/MS calculated for [M+H]+ C27H25N2: 377.2, found: 377.1.

Workup

  1. customsimilar yield as example 1, step 3

Sources & evidence

ORD record
ord-39509b719e444ccba37febc613518329
Source dataset
uspto-grants-2012_04
Patent number
US08153671B2

Reaction notes

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