3-Chloro-2-fluoroaniline → HCID 57618493, compound

Participants

Reaction Steps

The title material is prepared in 29% yield by reacting N-(1-Oxo-indan-5-yl)-methanesulfonamide and (4′-Fluoro-3′-methyl-biphenyl-3-yl)-hydrazine hydrochloride (prepared as in example 70, steps 1 and 2 except using 3-methyl-4-fluorophenylboronic acid and 3-chloro-2-fluoroaniline as the coupling partners) in an analogous manner to example 1, step 3 except that purification is accomplished by reverse phase UV triggered HPLC: 1H NMR (400 MHz, d6-DMSO) δ 12.08 (s, 1H), 9.75 (s, 1H), 7.61 (d, J=8.1 Hz, 1H), 7.55-7.50 (m, 1H), 7.48-7.40 (m, 3H), 7.28-7.22 (m, 2H), 7.14-7.09 (m, 1H), 3.74 (s, 2H), 3.01 (s, 3H), 2.34-2.31 (m, 3H); LC/MS calculated for [M+H]+ C23H18F2N2O2S: 425.1, found: 425.1.

Provenance & Evidence