HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (R)-3-(benzyloxy)propane-1,2-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | (+)-Solketal | HCID 736057 | — |
| Solvent | P-Xylene | HCID 7809 | — |
| Product | (R)-3-(benzyloxy)propane-1,2-diol | HCID 2724795 | — |
Reaction Steps
To this end, 1,2-isopropylidene-sn-glycerol is dissolved in p-xylene and stirred with the addition of potassium-tert.-butylate and benzyl chloride. Upon completion of the reaction, water and diisopropyl ether are added in equal parts; and a phase separation is carried out. The 3-benzyl-sn-glycerol in the upper phase is obtained by evaporation and subjected to additional cleaning steps.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153676B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-b013f26aba9a4d79b1aa64758794e654 |
| Source note | uspto-grants-2012_04 |