5-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole → HCID 59309386, compound

HRID 1690780Notes

Reaction equation

HRID 1690780 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:8]=[C:9]3[C:13](=[CH:14][CH:15]=2)[CH2:12][NH:11][CH2:10]3)[CH2:3][CH2:2]1.[CH:16]([O:19][C:20]1[CH:28]=[CH:27][C:26]([S:29]([CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])(=[O:31])=[O:30])=[CH:25][C:21]=1[C:22](O)=[O:23])([CH3:18])[CH3:17]>>[CH:16]([O:19][C:20]1[CH:28]=[CH:27][C:26]([S:29]([CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])(=[O:31])=[O:30])=[CH:25][C:21]=1[C:22]([N:11]1[CH2:10][C:9]2[C:13](=[CH:14][CH:15]=[C:7]([CH:4]3[CH2:5][CH2:6][O:1][CH2:2][CH2:3]3)[CH:8]=2)[CH2:12]1)=[O:23])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 577536035-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindoleHCID 59309385HCID 59309385, compound

Product 1

HCID 59309386HCID 59309386, compound

Procedure

In analogy to the procedure described for the synthesis of example 1, step 2, the title compound was prepared from 5-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole (CAS: 905274-50-2) and 2-isopropoxy-5-(2-trimethylsilanyl-ethanesulfonyl)-benzoic acid. MS (m/e): 529.3 [M]+.

Workup

  1. customIn analogy to the procedure described for the synthesis of example 1, step 2

Sources & evidence

ORD record
ord-ce9a41830b9b41aab1dc8ea42e11b9c8
Source dataset
uspto-grants-2012_04
Patent number
US08153679B2

Reaction notes

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