2-Chloro-5-(difluoromethoxy)phenyl-3-hydroxypropanenitrile → 3-Acetoxy-2-(4-chloro-2-methylphenyl)propanenitrile

Participants

Reaction Steps

This ester was prepared using the procedure described in Example 5, except 2(-2-(4-chloro-2-methylphenyl)-3-hydroxypropanenitrile was used in place of 2-(2-chloro-5-(difluoromethoxy)phenyl-3-hydroxypropanenitrile. The preparation of 2(2-(4-chloro-2-methylphenyl)-3-hydroxypropanenitrile is described in Example 11. The recovered ester product was a white solid (74% yield in two crops), m. p. 61-63° C.

Provenance & Evidence