Acetone → HCID 24991590, compound

Participants

Reaction Steps

This ester was prepared using the procedure described in Example 5, except 2-(4-chlorophenyl)-3-hydroxybutanenitrile was used in place of 2-(2-chloro-5-(difluoromethoxy)phenyl)-3-hydroxypropanenitrile. The preparation of 2-(4-chlorophenyl)-3-hydroxybutanenitrile is described in Example 17. The recovered ester product was a mixture of diastereoisomers (85% yield), Rf 0.29 and 0.35 (silica gel, acetone:hexane=1:3).

Provenance & Evidence