反应详情

To a mixture of (2-amino-6-methoxymethyl-pyridin-3-yl)methanol (260 mg, 1.5 mmol) described in Manufacturing Example 26-1-5 and methylene chloride (15 mL) was added manganese dioxide (1.3 g, 15 mmol), which was stirred overnight at room temperature. The reaction mixture was filtered through a Celite pad, and the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:heptane=3:2) to obtain the title compound (210 mg, 81%).

1. filtrationThe reaction mixture was filtered through a Celite pad
2. concentrationthe filtrate was concentrated under a reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate:heptane=3:2)