反应详情

To a mixture of 2-benzyl-5-((E)-2-nitro-vinyl)-pyridine (1.2 g, 5.0 mmol) described in Manufacturing Example 210-1-5, acetic acid (300 mg, 5.0 mmol), and dimethyl sulfoxide (10 mL) was added sodium borohydride (94 mg, 2.5 mmol), which was stirred for 10 minutes at room temperature. The reaction solution was partitioned into ethyl acetate and water. The organic layer was separated and passed through a glass filter provided with NH silica gel (eluted with ethyl acetate). The eluate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1) to obtain the title compound (260 mg, 22%).

1. customThe reaction solution was partitioned into ethyl acetate and water
2. customThe organic layer was separated
3. filtrationfilter
4. customprovided with NH silica gel (eluted with ethyl acetate)
5. concentrationThe eluate was concentrated under reduced pressure
6. customthe residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1)