Potassium Carbonate → HCID 86649036, compound

Participants

Reaction Steps

To a suspension of 6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-7-[(trimethylsilyl)ethynyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine (414 mg, 0.75 mmol) in MeOH (40 mL) was added K2CO3 (306 mg, 3.00 mmol). The reaction was stirred at rt for 1.5 h, diluted with H2O, and the product was extracted with EtOAc. The combined organic extracts were washed with H2O, brine, dried over MgSO4, filtered and concentrated. The resulting residue was purified by silica gel chromatography to give the title compound. 1H NMR (500 MHz, (CD3)2CO): δ 8.50 (s, 1H), 7.76 (d, 1H), 7.40 (m, 4H), 7.27 (m, 1H), 7.15 (d, 3H), 5.27 (d, 1H), 4.70 (d, 1H), 3.81 (s, 1H). LCMS: m/z 514.1 (m+H).

Provenance & Evidence