反应详情

To 2-(4-bromophenyl)propan-2-ol (8.3 g, 38.59 mmol) in 100 mL of CH2Cl2 was added DAST (6.1 mL, 46.31 mmol) at −78° C. The reaction was stirred to rt overnight, and quenched with 100 mL of water at 0° C. The product was extracted with EtOAc, and the extracts were washed with water (50 mL) and brine (50 mL), dried over anhydrous MgSO4, and concentrated to give 1-bromo-4-(1-fluoro-1-methylethyl)benzene, which was used without further purification.

1. customquenched with 100 mL of water at 0° C
2. extractionThe product was extracted with EtOAc
3. washthe extracts were washed with water (50 mL) and brine (50 mL)
4. dry with materialdried over anhydrous MgSO4
5. concentrationconcentrated