2,3-Diaminotoluene → HCID 66901679, compound

Participants

Reaction Conditions

Reaction Steps

A well-stirred mixture of 3-methyl-1,2-benzenediamine (4.0 g, 33 mmol) and 2-chloro-6-(trifluoromethyl)nicotinic acid (7.3 g, 33 mmol) in 2-butoxyethanol (60 ml) was heated at 140-150° C. for 6 h. The dark solution was then poured over crushed ice, and the resulting dark brown solid was collected, washed with water, and dried. Recrystallization from 50% dioxane/water afforded 7-methyl-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one.

Provenance & Evidence