Lithium Hydroxide → HCID 59618786, compound

Participants

Reaction Steps

To methyl-{3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]-1H-pyrazol-1-yl}acetate (Example 433, 3.5 mg, 0.006 mmol) in acetonitrile (0.5 mL) and water (0.5 mL) was added LiOH (2 mg, 0.005 mmol). After stirring overnight at rt, the reaction was diluted with 2 mL of brine, 0.5 mL of 2N HCl, and 20 mL of EtOAc. The organic layer was separated, washed with water and brine, dried with Na2SO4, and concentrated to give the title compound. 1H NMR (500 MHz, (CD3OD): δ 8.05 (brd s, 1H), 7.91 (brd s, 1H), 7.63 (s, 1H), 7.61 (d, 1H), 7.44 (d, 1H), 7.18 (d, 2H), 7.06 (d, 1H), 7.02 (d, 1H), 6.96 (d, 2H), 5.02 (s, 2H), 1.23 (s, 9H). LCMS: m/e 586.2 (M+H)+.

Provenance & Evidence