Isopropylamine → HCID 59618743, compound

HRID 1691479Notes

Reaction equation

[CH3:1][C:2]([C:7]1[CH:8]=[CH:9][C:10]2[NH:16][C:15]3[N:17]=[C:18]([C:21]([F:24])([F:23])[F:22])[CH:19]=[CH:20][C:14]=3[CH2:13][N:12]([S:25]([C:28]3[CH:33]=[CH:32][C:31]([O:34][C:35]([F:38])([F:37])[F:36])=[CH:30][CH:29]=3)(=[O:27])=[O:26])[C:11]=2[CH:39]=1)([CH3:6])[C:3](O)=[O:4].[CH:40]([NH2:43])([CH3:42])[CH3:41]>>[CH:40]([NH:43][C:3](=[O:4])[C:2]([CH3:6])([C:7]1[CH:8]=[CH:9][C:10]2[NH:16][C:15]3[N:17]=[C:18]([C:21]([F:23])([F:22])[F:24])[CH:19]=[CH:20][C:14]=3[CH2:13][N:12]([S:25]([C:28]3[CH:29]=[CH:30][C:31]([O:34][C:35]([F:38])([F:36])[F:37])=[CH:32][CH:33]=3)(=[O:26])=[O:27])[C:11]=2[CH:39]=1)[CH3:1])([CH3:42])[CH3:41]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 59618649HCID 59618649, compound

Product 1

HCID 59618743HCID 59618743, compound

Procedure

The title compound was prepared from 2-methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]propanoic acid (Example 382) and isopropylamine using the procedure described in Example 516 to afford the title compound; Mass Spectrum: m/e=617 (M+1).

Sources & evidence

ORD record: ord-d54add0c8e444de3b42b4e01ac6fe6e7
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08153626B2

Reaction notes

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