Chlorotrimethylsilane → HCID 66905089, compound

HRID 1691601Notes

Reaction equation

HRID 1691601 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:6]([OH:8])=[O:7].[CH3:15][Si]([Cl:19])(C)C>CO>[ClH:19].[NH2:2][CH2:3][CH2:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:6]([O:8][CH3:15])=[O:7]

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 468640804-Amino-2-phenylbutanoic acid--hydrogen chloride (1/1)

Product 1

HCID 66905089HCID 66905089, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of 1 g (4.64 mmol) of 4-amino-2-phenylbutyric acid hydrochloride and 0.67 ml (5.1 mmol) of trimethylsilyl chloride in 50 ml of methanol is heated at reflux for 2 hours. The mixture is subsequently stirred at 20° C. for 12 hours and then concentrated under reduced pressure, triturated in 50 ml of ethyl ether and then filtered. This gives 0.9 g of the expected product in the form of a white solid.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 2 hours
  3. concentrationconcentrated under reduced pressure
  4. customtriturated in 50 ml of ethyl ether
  5. filtrationfiltered

Sources & evidence

ORD record
ord-59674cac588f4626a676a49dfa2f420b
Source dataset
uspto-grants-2012_04
Patent number
US08153796B2

Reaction notes

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