1,4-Dioxane hydrochloride → HCID 66905927, compound

HRID 1691705Notes

Reaction equation

HRID 1691705 reaction equation
C(OC([N:8]([CH2:45][C:46]([OH:48])=[O:47])[CH2:9][C:10]([N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][N:19](C(OC(C)(C)C)=O)[C@@H:20]([C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24][CH:23]=2)[CH3:21])[CH:14]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH2:13]1)=[O:11])=O)(C)(C)C.[ClH:49].O1CCOCC1>>[ClH:49].[C:22]1([C@H:20]([NH:19][CH2:18][CH:15]2[CH2:16][CH2:17][N:12]([C:10](=[O:11])[CH2:9][NH:8][CH2:45][C:46]([OH:48])=[O:47])[CH2:13][CH:14]2[C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH3:21])[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 66906033HCID 66906033, compound

Product 1

HCID 66905927HCID 66905927, compound

Procedure

To 138 mg of [(tert-butoxycarbonyl){2-[4-({(tert-butoxycarbonyl)[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]-2-oxoethyl}amino]acetic acid was added 2.0 mL of a 4 M hydrogen chloride/1,4-dioxane solution. After stirring at room temperature for 2 hours, the reaction mixture was concentrated under reduced pressure, and to the obtained residue were added isopropanol and diisopropylether, and the precipitated solid was collected by filtration to obtain 83.9 mg of ({2-[4-({[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]-2-oxoethyl}amino)acetic acid hydrochloride as a white solid.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. additionto the obtained residue were added isopropanol and diisopropylether
  3. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-a0bdb495f5bd46bf942bc60f5354841c
Source dataset
uspto-grants-2012_04
Patent number
US08153658B2

Reaction notes

Loading…