1,4-Dioxane hydrochloride → HCID 66905999, compound

Participants

Reaction Steps

To 193 mg of 4-({[4-({(tert-butoxycarbonyl)[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]carbonyl}oxy)benzoic acid was added 2.0 mL of a 1,4-dioxane, and 2.0 mL of a 4 M hydrogen chloride/1,4-dioxane solution, followed by stirring at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, the residue was heated in isopropanol under reflux, and the mixture was left to be cooled at room temperature. The precipitate was collected by filtration, and dried under reduced pressure to obtain 117 mg of 4-({[4-({[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]carbonyl}oxy)benzoic acid hydrochloride as a white solid.

Provenance & Evidence