1,4-Dioxane hydrochloride → HCID 66906098, compound

Participants

Reaction Steps

To 142 mg of the crude product of 6-[4-({(tert-butoxycarbonyl)[(1R)-1-(3-methoxyphenyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]-5-chloronicotinic acid was added 2.0 mL of a 4 M hydrogen chloride/1,4-dioxane solution. After stirring at room temperature for 2 hours, the reaction mixture was concentrated under reduced pressure, and to the obtained residue was added ethanol and ethyl acetate, followed by heating under reflux, and then being left to be cooled to room temperature. Then, the precipitate was collected by filtration, and dried under reduced pressure to obtain 78 mg of 5-chloro-6-[4-({[(1R)-1-(3-methoxyphenyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]nicotinic acid hydrochloride as a white solid.

Provenance & Evidence