Diisopropyl Ether → 2-[3-(3-fluorophenyl)-4-({[(1R)-1-(1-naphthyl)ethyl]amino}methyl)piperidin-1-yl]-1H-benzimidazole-6-carboxylic acid dihydrochloride

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Reaction Steps

A solution of 19 mg of 2-[4-({(tert-butoxycarbonyl)[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-(3-fluorophenyl)piperidin-1-yl]-1H-benzimidazole-6-carboxylic acid in 1.00 mL of 4 M hydrogen chloride/1,4-dioxane solution was stirred at room temperature for 2 hours. Diisopropyl ether was added thereto, and the resulting precipitate was collected by filtration, and dried under reduced pressure to obtain 15 mg of 2-[3-(3-fluorophenyl)-4-({[(1R)-1-(1-naphthyl)ethyl]amino}methyl)piperidin-1-yl]-1H-benzimidazole-6-carboxylic acid dihydrochloride.

Provenance & Evidence