1,4-Dioxane hydrochloride → HCID 66905862, compound

Participants

Reaction Steps

To 265 mg of the crude 5-[4-({(tert-butoxycarbonyl)[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]-3,3-dimethyl-5-oxopentanoic acid was added 2.0 mL of a 4 M hydrogen chloride/1,4-dioxane solution, followed by stirring at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and the obtained residue was then suspended in isopropanol under heating, and then left to be cooled. The precipitate was isolated by filtration, and dried under reduced pressure to obtain 189 mg of 3,3-dimethyl-5-[4-({[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]-5-oxopentanoic acid hydrochloride as a white solid.

Provenance & Evidence