Dicyclopropylmethylamine hydrochloride → HCID 178513036, compound

HRID 1691771Notes

Reaction equation

HRID 1691771 reaction equation
Cl.[CH:2]1([CH:5]([NH2:9])[CH:6]2[CH2:8][CH2:7]2)[CH2:4][CH2:3]1.[C:10]([NH:12][C:13]([NH2:15])=[NH:14])#[N:11]>CCCCCCCCCC.C1(C)C=CC=CC=1>[CH:2]1([CH:5]([NH:9][C:10]([NH:12][C:13]([NH2:15])=[NH:14])=[NH:11])[CH:6]2[CH2:8][CH2:7]2)[CH2:4][CH2:3]1

Participants

5

Reactant 2

HCID 16613886Dicyclopropylmethylamine hydrochlorideHCID 178418324HCID 178418324, compound

Product 1

HCID 178513036HCID 178513036, compoundYield 80.6%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolvent2×HCID 15600DecaneSolvent

Procedure

1.6 g (10.8 mmol) of 1,1-dicyclopropylmethylamine hydrochloride were admixed with 0.91 g (10.8 mmol) of cyanoguanidine in a mixture of 6 ml of decane and 20 ml of toluene. The mixture was heated to a temperature of 140° C. for 5 h, in the course of which toluene distilled off. The flask contents were cooled to room temperature, then acetone was added. The precipitate was decanted off and freed of residual solvent under reduced pressure. 1.7 g of the crude product (purity approx. 80%) were obtained, which were used for the next synthesis stage without further purification.

Workup

  1. distillationdistilled off
  2. additionacetone was added
  3. customThe precipitate was decanted off

Sources & evidence

ORD record
ord-c2353c719ba14b2f968d2c7799f3399e
Source dataset
uspto-grants-2012_04
Patent number
US08153788B2

Reaction notes

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