HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → (2-Bromo-5-methoxy-4-methyl-phenyl)-acetic acid chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (2-Bromo-5-methoxy-4-methylphenyl)acetic acid | HCID 291672 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2-Bromo-5-methoxy-4-methyl-phenyl)-acetic acid chloride | HCID 59377714 | — |
Reaction Steps
To a solution of (2-bromo-5-methoxy-4-methyl-phenyl)-acetic acid (149.4 mg) in dichloromethane (1.8 mL) was added oxalyl chloride (0.055 mL) followed by DMF (1 drop) uder argon. Mixture was stirred at rt for 3 h. Mixture was concentrated to dryness. Dichloroethane (ca. 10 mL) was added, and the mixture was back concentrated to dryness to obtain crude (2-bromo-5-methoxy-4-methyl-phenyl)-acetic acid chloride (151 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153808B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-ac473a77240f48d9a5d40899e3546efe |
| Source note | uspto-grants-2012_04 |