Bromine → HCID 13657735, compound

HRID 1691783Notes

Reaction equation

HRID 1691783 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Br:14]Br>C(O)(=O)C>[Br:14][C:5]1[CH:6]=[C:7]([O:8][CH3:9])[C:2]([OH:1])=[CH:3][C:4]=1[CH2:10][C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 1605623-Hydroxy-4-methoxybenzeneacetic acid

Product 1

HCID 13657735HCID 13657735, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 3-hydroxy-4-methoxy-phenyl acetic acid (8 g) in 150 ml acetic acid was added drop wise 2.48 ml bromine. The mixture was stirred 18 hours at room temperature under nitrogen. The solvent was then removed in vacuo and the residue was triturated with toluene, filtered, washed with toluene then hexane to yield 11.1 g (2-bromo-5-hydroxy-4-methoxy-phenyl)-acetic acid a solid.

Workup

  1. customThe solvent was then removed in vacuo
  2. customthe residue was triturated with toluene
  3. filtrationfiltered
  4. washwashed with toluene

Sources & evidence

ORD record
ord-cf702df1b4f740439881017b624ec1b8
Source dataset
uspto-grants-2012_04
Patent number
US08153808B2

Reaction notes

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