Water → HCID 59377681, compound

HRID 1691788Notes

Reaction equation

HRID 1691788 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[O:12][CH3:13].[Br:14]Br.O>CC(O)=O>[Br:14][C:6]1[CH:7]=[C:2]([F:1])[C:3]([O:12][CH3:13])=[CH:4][C:5]=1[CH2:8][C:9]([OH:11])=[O:10]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 26188830HCID 26188830, compound

Product 1

HCID 59377681HCID 59377681, compoundYield 87.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 4-fluoro-3-methoxyphenylacetic acid (5.0 g, 27.1 mmol) in AcOH (20 ml) was added bromine (1.5 ml, 29.8 mmol). The mixture was stirred at room temperature for three hours. Water was added and the precipitate was isolated by filtration. The white solid was washed with water and dried to give (2-bromo-4-fluoro-5-methoxy-phenyl)-acetic acid (6.21 g, 87%).

Workup

  1. customthe precipitate was isolated by filtration
  2. washThe white solid was washed with water
  3. customdried

Sources & evidence

ORD record
ord-284b0afc0a1f4c049982bd6e7e3cc3dd
Source dataset
uspto-grants-2012_04
Patent number
US08153808B2

Reaction notes

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